19 junho 2015
digg: This monstrosity is what it looks like when you ask a...
digg:
This monstrosity is what it looks like when you ask a computer to identify and enhance what it sees in an image.
There’s a lot to learn about Artificial Neural Networks, but just know it’s computer trying to do normal human stuff like figure out what a squirrel is.
Genetic variation of stress hormone receptor may affect vulnerability to major depression
Scientists are beginning to unwrap the biology behind why some people are more prone to major depression and other psychiatric disorders than others when experiencing stressful life events. The researchers found that cellular activity in response to stress hormone receptor activation differs from individual to individual. The study, led by Janine Arloth, Ryan Bogdan, and Elisabeth Binder at the Max Planck Institute of Psychiatry in Germany, also shows that the genetic variations underlying this difference in stress response correlate with dysfunction in the amygdala, a brain region that is an important part of the stress hormone response. (Watch the paper’s video abstract on YouTube)
Link between schizophrenia and individual variations in GABA and glutamate transmission grows stronger
New evidence suggests that schizophrenics possess mutations affecting genes associated with GABA, a neurotransmitter that relaxes nervous system activity. The analysis, which included the largest sample size to date – comparing the genes of 11,500 people with schizophrenia to 16,500 people without the disorder – also replicated and expanded upon previous research implicating schizophrenia with genes related to the excitatory neurotransmitter glutamate. Neuroscientists Andrew Pocklington, Michael O'Donovan, and Michael Owen of Cardiff University led the study, which did not find significant differences between the two groups in genes unrelated to the central nervous system.
The authors believe that the risk of schizophrenia depends on the total burden of mutations and that no single gene can be blamed for acquiring the disorder. Mutations in genes that can disrupt GABA and glutamate signaling, however, appear more likely than others to be associated with schizophrenia among the most clearly involved.
‘Perturbation of these processes is likely to have a widespread impact on brain function, and only a subset of genetic lesions within these systems may be compatible with a schizophrenia phenotype,’ write the authors. ‘The identification of the mechanisms by which disruption of these processes by genetic mutation leads to psychopathology will doubtless require experimental studies in model systems of high construct validity.’
An argument to pinpoint the GABA receptor as a drug target for neurodevelopmental disorders
Thousands of genes have been linked to neurodevelopmental disorders, including autism and epilepsy, complicating attempts to find any one particular drug or therapy that could help patients. One lead from gene sequencing studies is the revelation that many of the genes associated with these disorders converge on a limited number of functional pathways.
Geneticists Sien Braat and R. Frank Kooy of the University of Antwerp argue that one intriguing commonality between neurodevelopmental disorders is a disturbance in the function of GABA signaling, responsible for preventing too much brain activity. Based on research using drugs targeting GABA signaling to treat fragile X syndrome in animal models, the researchers believe that clinical trials using these drugs (already approved for human use) would be worth pursuing for a wider range of neurodevelopmental disorders.
'Due to the genetic heterogeneity observed, targeted treatment aimed at interference with pathways commonly disturbed in multiple disorders might be the only realistic option,’ write the authors. 'Results of preclinical trials in several [neurodevelopmental] disorders have shown encouraging results and raised hopes for treatment in patients.’
Oração da Serenidade
Deus,Conceda-me a serenidadePara aceitar aquilo que não posso mudar,
A coragem para mudar o que me for possível
E a sabedoria para saber discernir entre as duas.
Vivendo um dia de cada vez,
Apreciando um momento de cada vez,
Recebendo as dificuldades como um caminho para a paz,
Aceitando este mundo cheio de pecados como ele é,
assim como fez Jesus, e não como gostaria que ele fosse;
Confiando que o Senhor fará tudo dar certo
Se eu me entregar à Sua vontade;
Pois assim poderei ser razoavelmente feliz nesta vida
E supremamente feliz ao Seu lado na outra.
Amém.
In October 1954, the first Prime Minister of India, Jawaharlal...
In October 1954, the first Prime Minister of India, Jawaharlal Nehru set off on what was described as the “most important foreign mission of his life.” He was visiting China, which had ended its civil war just three years before. To read about the historic rapprochement between the two up-and-coming Asian powerhouses, check out my latest post at historical-nonfiction
clouds over the aleutian islands, photographed by terra &...
clouds over the aleutian islands, photographed by terra & aqua, july 2015.
12 frames, photographed 13th-19th july. the bottom left gif gives the outlines of the islands and their names as they are usually written in english. bottom right gives the names in their native languages, where available (white).
image credit: nasa/modis. animation: ageofdestruction.
age
spytap: breakthecitysky: Today the system and philosophy of...
Today the system and philosophy of institutionalized racism identified by Dr. King no longer exists.
Read that sentence again.
I would love to know what universe the editorial board of the Wall Street Journal lives in.
Oh wait, it’s this one, it’s just that they’re privileged enough to believe this bullshit.
(photo via @deray on Twitter.)
Since 2007, the Wall Street Journal has been owned by the same people who own and operate Fox News. While the WSJ used to be the top tier in terms of reporting and educated (if conservative leaning, but educated conservative) editorial, upon purchase in 2007, their editorial section immediately became an ultra-right wing GOP talking points section unconcerned with fact, figure or bias - just like Fox News. Today it routinely denies climate change and is often written or contributed to by Fox News editors, hosts, and staff. It’s best to understand that the WSJ is just another NewsCorp propaganda tool now, so when the same song and dance echoes through the halls, remember that it’s because the same people are singing and dancing, and hoping you don’t notice.
Remember Tywanza Sanders:
xicanasol: “Hero who died standing between race-hate killer and his 87-year-old aunt, before the...
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Chinese sword with gold hilt, dating from the Spring and Autumn...
Chinese sword with gold hilt, dating from the Spring and Autumn period (770–476 BCE), found in a tomb in Shaanxi. Look at that detailing! Wow.
"Jeb Bush: “I don’t know if the Charleston shooting was racially motivated. It might just be..."
“Jeb Bush: “I don’t know if the Charleston shooting was racially motivated. It might just be...
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i-want-cheese: So with Bernie Sanders picking up a bit in popularity, I thought I’d bite the bullet...
i-want-cheese: So with Bernie Sanders picking up a bit in popularity, I thought I’d bite the bullet...
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Duas simpatias para passar no vestibular
Uma das coisas que mais nos apavora é o futuro, por isso sempre tentamos garantí-lo no presente. Deste modo aprendemos a ter cuidado com o que falamos para não afetar uma relação, começamos a guardar dinheiro para comprar algo necessário como uma casa ou um carro, mas o que é seguro e nos garante uma vida melhor no dia de amanhã, já dizia os nossos pais, será o nosso estudo.
Passar pelos três primeiros passos dos estudos (jardim de infância, fundamental e ensino médio) é fácil, todos conseguem entrar em uma escola. Estudando e se esforçando conseguirão passar para o próximo ano até concluir o colegial.
Já na faculdade, as coisas complicam um pouco. Às vezes, nos matamos de estudar, e mesmo assim, no dia do vestibular, não parece ser o suficiente. Não por incapacidade, mas por nervosismo ou por conta da concorrência.
E o que fazer para garantir a aprovação na universidade que você tanto deseja? Estudar muito, se esforçar, fazer simulados, e ter fé poderá te ajudar. Existem duas simpatias incríveis que, acreditando no seu potencial, fará com que você passe no vestibular.
Primeira simpatia para passar no vestibular
Simpatia para o Santo Expedito te ajudar a passar no vestibular: Você vai precisar de uma garrafa de água de 500 ml, a oração que segue abaixo e de muita fé.
Oração a Santo Expedito
“Meu Santo Expedito das causas justas e urgentes interceda por mim junto ao Nosso Senhor Jesus Cristo, socorra-me nesta hora de aflição e nervosismo, meu Santo Expedito Vós que sois um Santo guerreiro, Vós que sois o Santo dos aflitos, Vós que sois o Santo dos desesperados, Vós que sois o Santo das causas urgentes, proteja-me. Ajuda-me, Dai-me força, coragem, calma e serenidade no momento da prova. Atenda meu pedido (realize seu pedido para ser aprovado(a) no concurso/vestibular). Meu Santo Expedito! Ajuda-me a superar estas horas difíceis, proteja de todos que possam me prejudicar, proteja minha família, atenda ao meu pedido com urgência. Devolva-me a paz e a tranqüilidade. Meu Santo Expedito! Serei grato pelo resto de minha vida e levarei seu nome a todos que têm fé. Muito obrigado(a).”
Faça esta simpatia para passar no vestibular uma noite antes da prova, antes de dormir. Pegue a garrafa de água com a mão direita e ore para o Santo Expedito. Após realizar a oração continue segurando a água e com fé reze um Pai-Nosso, uma Ave Maria e uma vez Santo Anjo e no final faça o sinal da cruz.
Depois das orações continue com os olhos fechados, imagine-se fazendo a prova tranquila e segura, ponha toda sua fé nesse momento. Na sequência, coloque a água próximo ao local onde você vai dormir e no dia seguinte leve essa garrafa e a consuma durante a realização da prova. Acredite, dará tudo certo no final.
Segunda simpatia para passar no vestibular
Banho com folha de hortelã para passar na prova
Você precisará de: água, panela, uma folha de hortelã e uma vela.
Essa simpatia é muito mais simples do que a anterior, porém não é menos poderosa. No dia antes da prova, ferva a água junto com a folha do hortelã. Depois, espere até que ela esfrie e tome um banho com a mistura. Ao se limpar, relembre tudo o que você estudou e sabe.
Após o banho acenda uma vela para o seu anjo da guarda e reze para que ele te dê uma boa noite de sonho.
No dia do vestibular, ao acordar, bata o pé direito no chão, e convoque seu anjo da guarda para te acompanhar e te ajudar durante a prova. Assim, se você mantiver a fé, conseguirá passar.
Não deixe de ler:
- Por que sonhamos? Entenda aqui
- Descubra a poderosa simpatia para reatar amizade
- Qual o significado de sonhar com acidente?
- Muitas brigas? Veja como terminar um relacionamento
Saiba como aproveitar o poder das cores
dylann roof has admitted to his crimes, specifically requested to sit net to state sen. rev. pinckey when he entered the church, and stated he was trying to start a race war. you can have a permanent seat if you’re still claiming this wasn’t a terrorist act or that this was about anything other than race.
revolutionarykoolaid: (x)
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I got nothing for you, in terms of jokes and sounds. Because of...
I got nothing for you, in terms of jokes and sounds. Because of what happened in South Carolina. And maybe if I wasn’t nearing the end of the run, or this wasn’t such a common occurrence, maybe I could’ve pulled out of the spiral, but I didn’t. So I honestly have nothing.
micdotcom: Over 87,000 people are calling for Charleston to...
Over 87,000 people are calling for Charleston to remove its Confederate flag
After the massacre in Charleston, South Carolina, left nine black people dead, all the official flags throughout the state flew at half-mast. All but one: the Confederate flag. The symbol of slavery remained full-mast, defiantly flying high at the S.C. State House. Now nearly 100,000 people are fighting back — but sadly, it will take great effort to get it removed.
orchidnectar: snakesenpai: nowyoukno: Source for more facts...
This is actually true!
“In some places, such as Nri, the royal python, éké, is considered a sacred and tame agent of Ala and a harbinger of good fortune when found in a home. The python is referred to asnne ‘mother’ in areas where the python is revered, it is a symbol of female beauty and gentleness. Killing of the python is expressly forbidden in these places and sanctions are taken against the killer including the funding of expensive human sized burials that are given to slain pythons.” (x)
And more thanks to kaijutegu:
“A public levy is made for giving elaborate burial rites when the python dies from natural causes. Every python has a human soul within it; this must be liberated by ritual after the death of the reptile. Any offence against the snake is an offence against the ancestor.” (x)
yes.
Night-Shining Clouds
This image of noctilucent clouds is a composite of several Aeronomy of Ice in the Mesosphere (AIM) satellite passes over the Arctic on June 10, 2015. The clouds appear in various shades of light blue to white, depending on the density of the ice particles. The instrument measures albedo—how much light is reflected back to space by the clouds.
from NASA http://ift.tt/1RgjOXB
via IFTTT
The Founding Fathers refused to include a reference to “Almighty God” into the U.S. Constitution....
The Founding Fathers refused to include a reference to “Almighty God” into the U.S. Constitution. The Confederate Constitution, however, wanted to appear more evangelical and included the phrase. In fact, the national motto of the Confederacy was Deo Vindice: “God will avenge.”
Lyme diseaseWhat is Lyme disease?Lyme disease is an infection...
Lyme disease
What is Lyme disease?
Lyme disease is an infection caused by a bacteria transmitted through the bite of an infected tick. In Ontario, Lyme disease is spread by the bite of a black-legged tick, commonly known as a deer tick. Most humans are infected through the bite of an immature tick called a nymph. Nymphs are tiny (less than 2 mm) and difficult to see; they feed during the spring and summer months.
Adult ticks are much larger and are more likely to be discovered and removed before they have had time to transmit the bacteria. Adult blacklegged ticks are most active during late summer and fall.
(More from Ottawa Public Health)
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